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Other words relating to disease and sickness.Plague is an infectious, epidemic disease caused by a bacterium. Pestilence is any virulent and highly infectious disease that can cause an epidemic or even a pandemic. The word can also be used about parasites causing large scale sickness and death, such as Guinea worm. Malady is any ailment or disease of the human body; especially, a lingering or deep-seated disorder; A moral or mental defect or disorder. Infection is the detrimental ...